(3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol

Base Information

• Chemical Name: (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol
• CAS No.: 265976-77-0
• Molecular Formula: C₄₁H₆₀O₁₅
• Molecular Weight: 792.918
• Mol file: 265976-77-0.mol

Synonyms:(3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol

Chemical Property of (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol

There total 5 articles about (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-benzoic acid methyl ester (265976-76-9) → (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol (265976-77-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/(SICI)1521-3773(19990816)38:16<2370::AID-ANIE2370>3.0.CO;2-T

Reference yield:

methanesulfonic acid 2-(2-methoxyethoxy)ethyl ester (60696-83-5) → (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol (265976-77-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 68 percent / K₂CO₃ / dimethylformamide / 24 h / 90 °C

2: 86 percent / LiAlH₄ / tetrahydrofuran / 24 h / 20 °C

3: 76 percent / CBr₄; PPh₃ / tetrahydrofuran / 20 °C

4: 99 percent / K₂CO₃ / acetone / 24 h / Heating

5: 88 percent / LiAlH₄ / tetrahydrofuran / 24 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; 1: Etherification / 2: Reduction / 3: Substitution / 4: Etherification / 5: Reduction;

DOI:10.1002/(SICI)1521-3773(19990816)38:16<2370::AID-ANIE2370>3.0.CO;2-T

Reference yield:

{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-phenyl}-methanol (265976-75-8) → (3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-phenyl)-methanol (265976-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / CBr₄; PPh₃ / tetrahydrofuran / 20 °C

2: 99 percent / K₂CO₃ / acetone / 24 h / Heating

3: 88 percent / LiAlH₄ / tetrahydrofuran / 24 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetone; 1: Substitution / 2: Etherification / 3: Reduction;

DOI:10.1002/(SICI)1521-3773(19990816)38:16<2370::AID-ANIE2370>3.0.CO;2-T

upstream raw materials:

3,5-bis-{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzyloxy}-benzoic acid methyl ester

methanesulfonic acid 2-(2-methoxyethoxy)ethyl ester

1-bromomethyl-3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-benzene

{3,5-bis-[2-(2-methoxy-ethoxy)-ethoxy]-phenyl}-methanol

Downstream raw materials:

C₄₁H₅₉BrO₁₄