(3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate

Base Information

• Chemical Name: (3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate
• CAS No.: 1027785-11-0
• Molecular Formula: C₄₄H₆₂N₂O₆SSi
• Molecular Weight: 775.138
• Mol file: 1027785-11-0.mol

Synonyms:(3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate

Chemical Property of (3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate

There total 1 articles about (3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(3S,4R,5S)-allyl 4-amino-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate (1027785-09-6) + N-(tert-butoxycarbonyl)-S-trityl-D-cysteine → (3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate (1027785-11-0)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1039/b718310k

Reference yield: 99.0%

(3S,4R,5S)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamide]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate (1027785-11-0) → (3S,4R,5S)-allyl 4-[(S)-2-amino-3-(tritylthio)propanamido]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate (1027785-12-1)

Guidance literature:

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/b718310k

upstream raw materials:

(3S,4R,5S)-allyl 4-amino-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate

Downstream raw materials:

(3S,4R,5S)-allyl 4-[(S)-2-amino-3-(tritylthio)propanamido]-3-(tert-butyldimethylsilyloxy)-5-methylheptanoate