(R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

Base Information

Chemical Name:(R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide
CAS No.:325789-59-1
Molecular Formula:C₂₃H₃₀N₂O₄
Molecular Weight:398.502
Hs Code.:

Synonyms:(R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

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Chemical Property of (R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

Chemical Property:

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Technology Process of (R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

There total 3 articles about (R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 107-85-7
1-amino-3-methylbutane

: 325789-58-0
(R)-2-[(phenylmethyl)carbonyl]amino-4-(4-hydroxyphenyl)-butyric acid

: 325789-59-1
(R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 11h;
DOI:10.1016/S0040-4020(00)00882-6

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 325789-59-1
(R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / aq. NaOH / 12 h / 0 - 23 °C

2: 81 percent / EDC; HOBT / dimethylformamide / 11 h / 0 - 23 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; 1: Condensation / 2: Condensation;
DOI:10.1016/S0040-4020(00)00882-6

Reference yield:

: 185617-14-5
(R)-homotyrosine hydrobromide

: 325789-59-1
(R)-N-(3-methylbutyl)-2-[[(phenylmethyl)carbonyl]amino]-4-(4-hydroxyphenyl)-butyric amide

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / aq. NaOH / 12 h / 0 - 23 °C

2: 81 percent / EDC; HOBT / dimethylformamide / 11 h / 0 - 23 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; 1: Condensation / 2: Condensation;
DOI:10.1016/S0040-4020(00)00882-6