2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 766539-28-0
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.276
• Hs Code.: 2934999090
• Mol file: 766539-28-0.mol

Synonyms:2-(4-tert-Butoxycarbonylmorpholin-2-yl)acetic acid;4-Boc-2-morpholineacetic acid;2-[4-[(2-Methylpropan-2-yl)oxycarbonyl]morpholin-2-yl]acetic acid;2-Carboxymethyl-morpholine-4-carboxylic acid tert-butyl ester;

Chemical Property of 2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 4.16E-07mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 388.2 °C at 760 mmHg
• PKA: 4.31±0.10(Predicted)
• Flash Point: 188.6 °C
• PSA: 76.07000
• Density: 1.179 g/cm³
• LogP: 1.03490
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-Morpholine-2-aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-51
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 5 articles about 2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.03%

(±)-tert-butyl 2-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate → 2-(4-(tert-butoxycarbonyl)morpholin-2-yl)acetic acid (766539-28-0,1257848-48-8,1257850-82-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 6h;

Reference yield:

C12H21NO5 (766539-39-3) → 2-(4-(tert-butoxycarbonyl)morpholin-2-yl)acetic acid (766539-28-0,1257848-48-8,1257850-82-0)

Guidance literature:

C₁₂H₂₁NO₅; With sodium hydroxide; water; In tetrahydrofuran;

With hydrogenchloride; water; In ethyl acetate; pH=5;

Reference yield:

(E)-4-(benzyl(2-hydroxyethyl)amino)but-2-enoate ethyl ester → 2-(4-(tert-butoxycarbonyl)morpholin-2-yl)acetic acid (766539-28-0,1257848-48-8,1257850-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 100 °C

2: palladium on activated charcoal; hydrogen / methanol / 10 h / 20 °C / 2585.81 Torr

3: triethylamine / dichloromethane / 20 °C

4: sodium hydroxide; water / methanol / 6 h / 20 °C

With palladium on activated charcoal; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In methanol; dichloromethane; toluene;

upstream raw materials:

C₁₂H₂₁NO₅

ethyl 4-(phenylmethyl)-2-morpholineacetate

(±)-ethyl 2-(morpholin-2-yl)acetate

Downstream raw materials:

(±)-tert-butyl 2-(2-hydroxyethyl)morpholine-4-carboxylate