5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Base Information

Chemical Name:5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one
CAS No.:1339944-44-3
Molecular Formula:C₂₂H₁₉ClF₄N₄O₄S
Molecular Weight:546.93
Hs Code.:

Synonyms:5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

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Chemical Property of 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

There total 4 articles about 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1339944-31-8
5-chloro-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

: 236739-02-9
2,4-difluoro-1-(methylsulfonyl)benzene

: 1339944-44-3
5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: 5-chloro-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

2,4-difluoro-1-(methylsulfonyl)benzene; In N,N-dimethyl-formamide; mineral oil; at 100 ℃; for 16h;

Reference yield:

: 887624-46-6
4-hydroxypiperidine-1-carboximidamide

: 1339944-44-3
5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; diethyl diazodicarboxylate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 16 h / 100 °C

With diethyl diazodicarboxylate; sodium hydride; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1339944-44-3
5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

3.1: triphenylphosphine; diethyl diazodicarboxylate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 16 h / 100 °C

With diethyl diazodicarboxylate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In N,N-dimethyl-formamide; mineral oil;