(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Name:(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:175355-60-9
Molecular Formula:C₂₈H₃₇N₅O₉S
Molecular Weight:619.696
Hs Code.:

(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Synonyms:(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 3 articles about (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 175355-50-7
(S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

: 175355-60-9
(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 20h;
DOI:10.1246/bcsj.69.431

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 175355-60-9
(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67.2 percent / NaHCO₃ / tetrahydrofuran / 2 h / Ambient temperature

2: 86.7 percent / DCC / tetrahydrofuran / 20 h / 0 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1246/bcsj.69.431

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 175355-60-9
(S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67.2 percent / NaHCO₃ / tetrahydrofuran / 2 h / Ambient temperature

2: 86.7 percent / DCC / tetrahydrofuran / 20 h / 0 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1246/bcsj.69.431