(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

Base Information

Chemical Name:(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate
CAS No.:1070764-28-1
Molecular Formula:C₃₅H₃₃ClF₆N₂O₅
Molecular Weight:711.101
Hs Code.:

(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

Synonyms:(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Useful:

Technology Process of (2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

There total 16 articles about (2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070764-25-8
(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-4-(2-methylphenyl)octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

: 4461-30-7
2-chloroacetylisocyanate

: 1070764-28-1
(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1070764-23-6
tert-butyl (3aR,4R,5S,7aS)-5-{(1S)-2-(benzoyloxy)-1-[3,5-bis-(trifluoromethyl)phenyl]ethoxy}-4-(2-methylphenyl)-octahydro-2H-isoindole-2-carboxylate

: 1070764-28-1
(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C

2: dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm400751p

Reference yield:

: 1070764-21-4
tert-butyl (3aR,4R,5S,7aS)-5-{1-[3,5-bis(trifluoromethyl)phenyl]-2-ethoxy-2-oxoethoxy}-4-(2-methylphenyl)-octahydro-2H-isoindole-2-carboxylate

: 1070764-28-1
(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-{[(3aR,4R,5S,7aS)-2-{[(chloroacetyl)amino]carbonyl}-4-(2-methylphenyl)-octahydro-1H-isoindol-5-yl]oxy}ethyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 75 °C / Inert atmosphere

2: pyridine / 16 h / 50 °C

3: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C

4: dichloromethane / 1 h / 0 - 20 °C

With pyridine; hydrogenchloride; lithium borohydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm400751p