N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1609341-56-1
Molecular Formula:C₂₂H₂₆F₂N₄O₂
Molecular Weight:416.471
Hs Code.:

Synonyms:N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

There total 5 articles about N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1415501-19-7
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid

: 75804-28-3
2,3-diamino-2,3-dimethylbutane bishydrochloride

: 1609341-56-1
N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2,3-diamino-2,3-dimethylbutane bishydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1609341-56-1
N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

With water; sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 151411-13-1
3-[(2,6-difluorobenzyl)oxy]pyridine-2-amine

: 1609341-56-1
N-(3-amino-2,3-dimethylbutan-2-yl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 24 h / Molecular sieve; Reflux

2.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;