3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

Base Information

Chemical Name:3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide
CAS No.:229342-64-7
Molecular Formula:C₁₉H₁₂Cl₄N₂O₂S
Molecular Weight:474.194
Hs Code.:

Synonyms:3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

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Chemical Property of 3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

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Technology Process of 3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

There total 9 articles about 3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 229342-99-8
3-chloro-4-(chloromethyl)-2-thiophenecarbonyl chloride

: 24680-04-4
2-amino-5-chloro-N-(4-chlorophenyl)benzamide

: 229342-64-7
3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2006.12.019

Reference yield:

: 175137-11-8
3-chloro-4-methyl-2-thiophenecarboxylic acid methyl ester

: 229342-64-7
3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / SO₂Cl₂; benzoyl peroxide / 17 h / Heating

2: HOAc / 24 h / Heating

3: NaOH / dioxane; H₂O / 1 h

4: SOCl₂ / 6 h / Heating

5: 5.1 g / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; sodium hydroxide; thionyl chloride; sulfuryl dichloride; acetic acid; dibenzoyl peroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2006.12.019

Reference yield:

: 229342-83-0
3-chloro-4-(chloromethyl)-2-thiophenecarboxylic acid methyl ester

: 229342-64-7
3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: HOAc / 24 h / Heating

2: NaOH / dioxane; H₂O / 1 h

3: SOCl₂ / 6 h / Heating

4: 5.1 g / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; sodium hydroxide; thionyl chloride; acetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2006.12.019