(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

Base Information

Chemical Name:(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate
CAS No.:1426668-75-8
Molecular Formula:C₂₃H₂₃F₃N₅O₆P
Molecular Weight:553.434
Hs Code.:

(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

Synonyms:(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

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Chemical Property of (S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

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Technology Process of (S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

There total 12 articles about (S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426668-73-6
(S)-dimethyl (1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl) phosphate

: 1426668-75-8
(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

Guidance literature:: With trimethylsilyl bromide; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 123-76-2
levulinic acid

: 1426668-75-8
(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 0.75 h / 125 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 0 - 20 °C

3.1: ChiralCel OD-H column / Resolution of racemate

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

4.2: 0.33 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: trimethylsilyl bromide / acetonitrile / 0 - 20 °C

With oxalyl dichloride; trimethylsilyl bromide; tetrabutyl ammonium fluoride; sodium hydride; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1426671-14-8
3-amino-N-hydroxy-4-methylbenzimidamide

: 1426668-75-8
(S)-1,1,1-trifluoro-2-methyl-4-(3-(4-methyl-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 0.75 h / 125 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 0 - 20 °C

3.1: ChiralCel OD-H column / Resolution of racemate

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

4.2: 0.33 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: trimethylsilyl bromide / acetonitrile / 0 - 20 °C

With oxalyl dichloride; trimethylsilyl bromide; tetrabutyl ammonium fluoride; sodium hydride; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;