(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

Base Information

Chemical Name:(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester
CAS No.:1404380-75-1
Molecular Formula:C₁₉H₁₆F₃NO₅
Molecular Weight:395.335
Hs Code.:

Synonyms:(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

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Chemical Property of (S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

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Technology Process of (S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

There total 1 articles about (S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 327-52-6
1-bromo-2,4,5-trifluorobenzene

: 1404380-74-0
(S)-3-((benzyloxycarbonyl)amino)-4-(methoxy(methyl)amino)-4-oxobutanoic acid methyl ester

: 1404380-75-1
(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

Guidance literature:: 1-bromo-2,4,5-trifluorobenzene; (S)-3-((benzyloxycarbonyl)amino)-4-(methoxy(methyl)amino)-4-oxobutanoic acid methyl ester; With isopropylmagnesium bromide; In tetrahydrofuran; at -10 - 20 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at -10 ℃; for 2h;

Reference yield:

: 1404380-75-1
(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

: 486460-32-6,823817-55-6
sitagliptin

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 2 h / 20 °C

1.2: pH 5.5

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h

3.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / -10 - 20 °C

3.2: 1 h / 0 - 40 °C

3.3: 12 h

With sodium tetrahydroborate; boron trifluoride diethyl etherate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1404380-75-1
(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

: 1374966-98-9
(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Guidance literature:: (S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=5.5;