(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Base Information

Chemical Name:(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid
CAS No.:1374966-98-9
Molecular Formula:C₁₈H₁₄F₃NO₅
Molecular Weight:381.308
Hs Code.:

Synonyms:(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Suppliers and Price of (S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

There total 6 articles about (S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40856-59-5,132957-40-5
tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

: 1374966-98-9
(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: chromic acid / 1.5 h / 20 °C

With chromic acid; magnesium; In tetrahydrofuran; 2.1: |Jones Oxidation;
DOI:10.1016/j.tetasy.2017.08.009

Reference yield:

: 1404380-75-1
(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester

: 1374966-98-9
(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Guidance literature:: (S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=5.5;

Reference yield:

: 327-52-6
1-bromo-2,4,5-trifluorobenzene

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 1374966-98-9
(S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoicacid

Guidance literature:: 1-bromo-2,4,5-trifluorobenzene; With isopropylmagnesium bromide; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one; With isopropylmagnesium bromide; In tetrahydrofuran; at -20 - 20 ℃; for 5.16667h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Cooling with ice;