2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride

Base Information

• Chemical Name: 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride
• CAS No.: 1446359-67-6
• Molecular Formula: C₁₇H₁₃F₂N₇O*ClH
• Molecular Weight: 405.794
• Mol file: 1446359-67-6.mol

Synonyms:2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride

Chemical Property of 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride

There total 2 articles about 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C30H21F2N7O (1446359-79-0) → 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride (1446359-67-6)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide (1446359-78-9) → 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride (1446359-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridine / 16 h / 110 °C

2: water; hydrogenchloride / tetrahydrofuran / 0.25 h / 20 °C

With pyridine; hydrogenchloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

Reference yield: 59.0%

1-Methyl-cyclopropanoic acid (6914-76-7) + 2-(1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride (1446359-67-6) → C22H19F2N7O2 (1446359-03-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In pyridine; dichloromethane;

upstream raw materials:

1-(2,3-difluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide

C₃₀H₂₁F₂N₇O

Downstream raw materials:

C₂₂H₁₉F₂N₇O₂

C₂₂H₁₆F₅N₇O₂

C₂₂H₁₆F₂N₈O₂

C₂₄H₁₆F₃N₇O₂