6914-76-7

Basic information

• Product Name: 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID
• Synonyms: 1-METHYLCYCLOPROPANECARBOXYLIC ACID;1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID;Cyclopropanecarboxylic acid, 1-methyl-;1-methyl cyclopropyl carboxylic acid;Einecs 230-020-7;1-Carboxy-1-methylcyclopropane;1-Methylcyclopropanecarboxylic acid 98%
• CAS NO: 6914-76-7
• Molecular Formula: C5H8O2
• Molecular Weight: 100.12
• EINECS: 230-020-7
• Product Categories: Carboxylic Acids;Cyclopropanes;Simple 3-Membered Ring Compounds;Carboxylic Acids;Ring Systems;Cycloalkanes;C1 to C5;Carbonyl Compounds;Building Blocks;C1 to C5;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 6914-76-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 30-32 °C(lit.)
• Boiling Point: 183-185 °C(lit.)
• Flash Point: 184 °F
• Appearance: WHITE TO YELLOW POWDER, CRYSTALS, CRYSTALLINE POWDER OR SOLID AND/OR CHUNKS
• Density: 1.283
• Vapor Pressure: 0.352mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.87±0.20(Predicted)
• Water Solubility: Slightly soluble in water
• BRN: 2039384
• CAS DataBase Reference: 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID(6914-76-7)
• EPA Substance Registry System: 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID(6914-76-7)

Safety Data

• Hazard Codes: C,N,T
• Statements: 34-50/53-36-25
• Safety Statements: 26-27-36/37/39-45-61-60
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 6914-76-7(Hazardous Substances Data)

Usage

Uses

1-Methylcyclopropanecarboxylic acid was used in the structure-activity studies of small carboxylic acids (SCAs). It was also used in the identification of selective orthosteric ligands for both free fatty acid receptor 2 (FFA2) and free fatty acid receptor 3 (FFA3).

InChI:InChI=1/C5H8O2/c1-5(2-3-5)4(6)7/h2-3H2,1H3,(H,6,7)

Synthetic route

1-Methylcyclopropancarbonsaeurenitril (78104-88-8) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With sodium hydroxide for 3h; Heating;	99%
With sodium hydroxide for 3h; Reflux;	87%
With sodium hydroxide

benzyl 2,2-dibromo-1-methylcyclopropylcarboxylate → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Stage #1: benzyl 2,2-dibromo-1-methylcyclopropylcarboxylate With sodium In tetrahydrofuran; ethanol; water; toluene at 20℃; for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water; toluene pH=1;	94.1%

benzyl 2,2-dichloro-1-methylcyclopropylcarboxylate → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Stage #1: benzyl 2,2-dichloro-1-methylcyclopropylcarboxylate With sodium In tetrahydrofuran; ethanol; water; toluene at 20℃; for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water; toluene pH=1;	93.3%

methyl 2,2-dichloro-1-methylcyclopropanecarboxylate (1447-13-8) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Stage #1: methyl 2,2-dichloro-1-methylcyclopropanecarboxylate With sodium In tetrahydrofuran; ethanol; water; toluene at 20℃; for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water; toluene for 0.5h; pH=1;	93.1%

2,2-dibromo-1-methylcyclopropanecarboxylic acid (5365-21-9) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With sodium In tetrahydrofuran; ethanol; water; toluene at 20℃; for 1h; Inert atmosphere;	92.7%

methyl 2,2-dibromo-1-methylcyclopropanecarboxylate (39647-01-3) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Stage #1: methyl 2,2-dibromo-1-methylcyclopropanecarboxylate With sodium In tetrahydrofuran; ethanol; water; toluene at 20℃; for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water; toluene pH=1;	92.7%

2,2-dichloro-1-methylcyclopropanecarboxylic acid (1447-14-9) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With sodium In tetrahydrofuran; ethanol; water; toluene at 20℃; for 1h; Inert atmosphere;	92.6%

2,6-di(tert-butyl)-4-methylphenyl 1-methylcyclopropanecarboxylate → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With potassium tert-butylate; water In tetrahydrofuran for 36h; Heating;	87%

1-methylcyclopropanecarboxamide (15910-91-5) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With sodium hydroxide for 3h; Reflux;	86%

1-methylcyclopropanecarboxylic acid ethyl ester (71441-76-4) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Stage #1: 1-methylcyclopropanecarboxylic acid ethyl ester With methanol; sodium hydroxide; water at 50 - 60℃; for 5h; Stage #2: With hydrogenchloride; water pH=1;	84%
Stage #1: 1-methylcyclopropanecarboxylic acid ethyl ester With sodium hydroxide In methanol at 60℃; Stage #2: With hydrogenchloride In methanol; water pH=2;

methyl 1-methylcyclopropanecarboxylate (6206-25-3) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With potassium hydroxide at 100℃; im Rohr;
(hydrolysis);
(saponification);
With hydrogenchloride; sodium hydroxide In methanol; 5,5-dimethyl-1,3-cyclohexadiene; water

carbon dioxide (124-38-9) + 2-methylallylmagnesium chloride (5674-01-1) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With water Irradiation;

1-(1-methylcyclopropyl)ethanone (1567-75-5) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With sodium hypobromide In water
With sodium hydroxide; sodium hypobromide; bromine

(1-methylcyclopropyl)benzene (2214-14-4) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With ozone

lithium α-lithiocyclopropanecarboxylate (110419-17-5) + methyl iodide (74-88-4) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
In tetrahydrofuran 1.) -20 deg C, 2.) to room temp., 1 h;	32 % Spectr.

methyl iodide (74-88-4) + cyclopropanecarboxylic acid (1759-53-1) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With lithium diisopropyl amide 1.) THF, 0 deg C, 10 min, 2.) room temperature, 1 h; Yield given. Multistep reaction;

1-methylcyclopropanecarbonyl chloride (16480-05-0) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With aluminium trichloride In benzene

diazomethane (186581-53-3, 908094-01-9) + methacrylic acid methyl ester (80-62-6) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
(i), (ii) (alkaline hydrolysis); Multistep reaction;

3-bromo-2-bromomethyl-2-methyl-propionic acid methyl ester (861588-29-6) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: zinc dust; methanol 2: aqueous-methanolic KOH-solution / 100 °C / im Rohr View Scheme

C9H16O2 (1346641-14-2) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
With hydrogenchloride; water In 1,4-dioxane at 20℃;

2,2-dichloro-1-methylcyclopropylcarboxamide (35749-17-8) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium / toluene; ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 2: sodium hydroxide / 3 h / Reflux View Scheme

2,2-dibromo-1-metil-ciclopropilcarbossamide (122665-05-8) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium / toluene; ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 2: sodium hydroxide / 3 h / Reflux View Scheme

2,2-dichloro-1-methylcyclopropanecarbonitrile (35757-05-2) → 1-Methyl-cyclopropanoic acid (6914-76-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium / toluene; ethanol; water / 1 h / 20 °C / Inert atmosphere 2: sodium hydroxide / 3 h / Reflux View Scheme

4-{5-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-ureido]-6-methyl-pyridin-2-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (936369-18-5) + 1-Methyl-cyclopropanoic acid (6914-76-7) → 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{2-methyl-6-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-pyridin-3-yl}-urea

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 22℃; for 18h;	100%

1-Methyl-cyclopropanoic acid (6914-76-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N,1-dimethylcyclopropane-1-carboxamide (608537-49-1)

Conditions	Yield
Stage #1: 1-Methyl-cyclopropanoic acid With oxalyl dichloride In diethyl ether at 0 - 20℃; for 11h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With pyridine In diethyl ether; chloroform at 0 - 20℃; for 23h; Inert atmosphere;	99%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	75.6%
Stage #1: 1-Methyl-cyclopropanoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride	63%

1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methylcyclopropanecarboxylic acid [1-(cyanomethylcarbamoyl)-2-naphthalen-2-ylethyl]amide (713531-19-2)

Conditions	Yield
Stage #1: 1-Methyl-cyclopropanoic acid With 1-hydroxybenzotriazole-6-sulfonamidomethyl polystyrene; benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 10h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 20h;	98%
Stage #1: 1-Methyl-cyclopropanoic acid With 1-hydroxybenzotriazole-6-sulfonamidomethyl polystyrene; benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 10h; Stage #2: With 1-hydroxybenzotriazole-6-sulfonamidomethyl polystyrene; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 20h;	98%

1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methylcyclopropanecarbonyl chloride (16480-05-0)

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide at -40 - 40℃; for 2h; Solvent; Temperature; Time; Reagent/catalyst;	96.8%
With thionyl chloride; N,N-dimethyl-formamide at 40℃; for 2h;	96.8%
With thionyl chloride for 3h; Heating;	95%

1-Methyl-cyclopropanoic acid (6914-76-7) + (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine (147081-44-5) → tert-butyl (3S)-3-{[(1-methylcyclopropyl)carbonyl]amino}pyrrolidine-1-carboxylate (887767-23-9)

Conditions	Yield
Stage #1: 1-Methyl-cyclopropanoic acid; (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane; ethyl acetate at 0 - 20℃; for 1h; Stage #2: With potassium carbonate In dichloromethane; water at 20℃; for 18h;	95%

1-Methyl-cyclopropanoic acid (6914-76-7) + N-(4-(piperidin-4-yl)phenyl)isoindoline-2-carboxamide → C25H29N3O2

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	95%

1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methylcyclopropanemethanol (2746-14-7)

Conditions	Yield
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether at 20℃; for 2h;	92%
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 20℃; for 72h;	70 g
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 18h; Inert atmosphere;
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h;

4-carbethoxypiperidine (1126-09-6) + 1-Methyl-cyclopropanoic acid (6914-76-7) → 1-(1-Methyl-cyclopropanecarbonyl)-piperidine-4-carboxylic acid ethyl ester (1198281-32-1)

Conditions	Yield
Stage #1: 1-Methyl-cyclopropanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 1h; Stage #2: 4-carbethoxypiperidine In dichloromethane at 20℃;	92%
Stage #1: 1-Methyl-cyclopropanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 1h; Stage #2: 4-carbethoxypiperidine In dichloromethane at 20℃;	92%

1-Methyl-cyclopropanoic acid (6914-76-7) + N-hydroxy-3,4,5,6-tetrachlorophthalimide (85342-65-0) → 4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl 1-methylcyclopropane-1-carboxylate

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane	91%

1-Methyl-cyclopropanoic acid (6914-76-7) + diethylamine (109-89-7) → 1-methyl-cyclopropanecarboxylic acid diethylamide (467426-60-4)

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h;	90%

1-Methyl-cyclopropanoic acid (6914-76-7) + methyl 4-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzoate hydrochloride → methyl 4-(5-methyl-2-((1-(1-(1-methylcyclopropanecarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzoate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;	90%

1-Methyl-cyclopropanoic acid (6914-76-7) + C13H18BrNO2S*ClH → C18H24BrNO3S

Conditions	Yield
With triethylamine; HATU In dichloromethane at 30℃; for 1h;	88.2%

1-Methyl-cyclopropanoic acid (6914-76-7) + 4-(4-bromophenyl)-5-[(3S)-3-pyrrolidinylmethyl]-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride (1332333-81-9) → 4-(4-bromophenyl)-5-({(3S)-1-[(1-methylcyclopropyl)carbonyl]-3-pyrrolidinyl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (1332333-87-5)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere; Microwave irradiation; Capped vial;	87%

1-Methyl-cyclopropanoic acid (6914-76-7) + (S)-dibenzyl 2-(2-(2-(benzyloxy)-2-oxoethoxy)-4-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate → (S)-dibenzyl 2-(2-(2-(benzyloxy)-2-oxoethoxy)-4-(5-((((R)-2-((R)-1-(N-((1-methylcyclopropanecarbonyl)oxy)formamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In acetonitrile for 1h;	87%

(1S,4S)-3-oxo-2-oxa-5-azonia-bicyclo [2.2.1]heptane methanesulfonate + 1-Methyl-cyclopropanoic acid (6914-76-7) → (1S,4S)-5-(1-methyl cyclopropanecarbonyl)-2-oxa-5-aza-bicyclo[2.2.1]heptan-3-one (1434816-54-2)

Conditions	Yield
Stage #1: 1-Methyl-cyclopropanoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 2 - 20℃; for 1.5h; Stage #2: (1S,4S)-3-oxo-2-oxa-5-azonia-bicyclo [2.2.1]heptane methanesulfonate With triethylamine In dichloromethane at 2 - 20℃; for 1.16667h;	86%

1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methylcyclopropylamine hydrochloride (88887-87-0)

Conditions	Yield
Stage #1: 1-Methyl-cyclopropanoic acid With diphenyl phosphoryl azide; triethylamine In tert-butyl alcohol at 20 - 75℃; for 16h; Stage #2: With hydrogenchloride In 1,4-dioxane; water for 3h;	85%
Stage #1: 1-Methyl-cyclopropanoic acid With diphenyl phosphoryl azide; triethylamine In tert-butyl alcohol at 75℃; Stage #2: With hydrogenchloride In 1,4-dioxane; water at 20℃; for 2h;	51%
Yield given. Multistep reaction;

1-(4-methyl-5-thiazolyl)-1-phenylmethanol (103985-97-3) + 1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methylcyclopropanecarboxylic acid (4-methyl-5-thiazolyl)-phenylmethyl ester (1392233-75-8)

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane	85%

1-Methyl-cyclopropanoic acid (6914-76-7) + 3-(piperidin-4-yl)-3,4-dihydro-1H-pyrano[4,3-c]isoquinolin-6(5H)-one (1520888-97-4) → rac-2-[1-(1-methylcyclopropanecarbonyl)piperidin-4-yl]-1,2,4,10-tetrahydro-3-oxa-10-azaphenanthren-9-one (1520889-49-9)

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	85%

1-Methyl-cyclopropanoic acid (6914-76-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(1-methylcyclopropanecarbonyl)piperazine-1-carboxylate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 0 - 20℃;	85%

1-Methyl-cyclopropanoic acid (6914-76-7) + 3-(m-tolylethynyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride → ((3r)-3-hydroxy-3-(m-tolylethynyl)-8-azabicyclo[3.2.1]octan-8-yl)(1-methylcyclopropyl)methanone

Conditions	Yield
With HATU; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2.5h;	83%

Upstream product

• 1447-14-9 2,2-dichloro-1-methylcyclopropanecarboxylic acid 
• 5365-21-9 2,2-dibromo-1-methylcyclopropanecarboxylic acid 
• 1447-13-8 methyl 2,2-dichloro-1-methylcyclopropanecarboxylate 
• 39647-01-3 methyl 2,2-dibromo-1-methylcyclopropanecarboxylate 
• 35749-17-8 2,2-dichloro-1-methylcyclopropylcarboxamide 
• 122665-05-8 2,2-dibromo-1-metil-ciclopropilcarbossamide 
• 15910-91-5 1-methylcyclopropanecarboxamide 
• 35757-05-2 2,2-dichloro-1-methylcyclopropanecarbonitrile 
• 1346641-14-2 C₉H₁₆O₂ 
• 71441-76-4 1-methylcyclopropanecarboxylic acid ethyl ester 
• 861588-29-6 3-bromo-2-bromomethyl-2-methyl-propionic acid methyl ester 
• 186581-53-3 diazomethane 
• 80-62-6 methacrylic acid methyl ester 
• 16480-05-0 1-methylcyclopropanecarbonyl chloride 

Downstream Products

• 15910-91-5 1-methylcyclopropanecarboxamide 
• 1567-75-5 1-(1-methylcyclopropyl)ethanone 
• 16480-05-0 1-methylcyclopropanecarbonyl chloride 
• 88887-87-0 1-methylcyclopropylamine hydrochloride 
• 633317-71-2 N-cyclopropyl-1-methylcyclopropane-1-carboxamide 
• 1001525-91-2 1-methylcyclopropanecarboxylic acid benzyl ester 
• 1022146-05-9 C₂₉H₂₈F₃N₅O₂ 
• 1346641-85-7 C₁₈H₁₄F₄N₂O 
• 1346641-89-1 C₂₆H₁₄F₁₀N₂O 
• 1346641-90-4 (Z)-ethyl 2-(3-(4-cyano-2,3,5,6-tetrafluorophenyl)-5-methyl-4-oxo-3-azabicyclo[3.1.0]hexan-2-ylidene)acetate 
• 1346641-87-9 C₂₀H₂₄F₄N₂O 
• 1346641-94-8 C₂₈H₂₄F₄N₂O 
• 1346641-78-8 N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-methyl-2,3-diphenylcyclopropanecarboxamide 

Relevant articles and documents

A process for preparing 1-methyl propyl formic acid method

The invention discloses a method for preparing 1-methyl cyclopropane carboxylic acid and belongs to the fields of fine chemical engineering and medical intermediates. The method comprises the following steps: by taking methacrylic acid (ester or salt), or methacrylonitrile or methacrylamide as a raw material, carrying out a cyclopropanation reaction with trihalide in the presence of an alkali to generate 2,2-geminal halide (III); carrying out a reaction between the 2,2-geminal halide (III) and metallic sodium to remove halogen atoms on the ring so as to generate methyl cyclopropionate or methyl cyclopropaneacetonitrile or methyl cyclopropylamide (II); acidifying the methyl cyclopropanecarboxylate, thereby obtaining 1-methyl cyclopropane carboxylic acid (I); and performing basic hydrolysis on methyl cyclopropaneacetonitrile or methyl cyclopropylamide, and acidifying to obtain 1-methyl cyclopropane carboxylic acid (I). The method disclosed by the invention is readily available in raw materials, mild in reaction conditions, convenient to operate, low in cost and high in purity of the obtained product and is a feasible preparation method.

Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes

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Process for the preparation of alkyl 1-methylcyclopropanecarboxylate

Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting γ-butyrolactone to α-methyl-γ-butyrolactone; (2) converting the α-methyl-γ-butyrolactone from step (1) to an alkyl 4-halo-2-methylbutyrate; (3) producing a xylene solution of the alkyl 4-halo-2-methylbutyrate; and (4) contacting the xylene solution of an alkyl 4-halo-2-methylbutyrate from step (3) with an alkali metal alkoxide under conditions of temperature and pressure which causes vaporization of (i) an alkanol as it is formed and (ii) an alkyl 1-methylcyclopropanecarboxylate as it is formed from the alkyl 4-halo-2-methylbutyrate. Also disclosed are processes whereby the alkyl 1-methylcyclopropanecarboxylate, prepared as described above, is converted to 1-methylcyclopropylamine.