2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

Base Information

Chemical Name:2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile
CAS No.:1384542-75-9
Molecular Formula:C₂₉H₂₉N₇
Molecular Weight:475.596
Hs Code.:

Synonyms:2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

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Chemical Property of 2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

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Technology Process of 2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

There total 5 articles about 2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1260539-15-8
4-bromo-2-(tert-butylamino)benzonitrile

: 1384542-72-6
3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazole

: 1384542-75-9
2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N-dimethylethylenediamine; In 1,4-dioxane; at 150 ℃;

Reference yield:

: 693285-71-1
4-bromo-3-isopropyl-1H-indazole

: 1384542-75-9
2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: copper(I) oxide; caesium carbonate; 8-quinolinol / dimethyl sulfoxide / 125 °C

3.1: trifluoroacetic acid / 5 h / 100 °C

4.1: caesium carbonate; copper(l) iodide; N,N-dimethylethylenediamine / 1,4-dioxane / 150 °C

With copper(I) oxide; copper(l) iodide; 8-quinolinol; sodium hydride; caesium carbonate; N,N-dimethylethylenediamine; trifluoroacetic acid; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3-isopropyl-1-(4-methoxybenzyl)-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazole

: 1384542-75-9
2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 5 h / 100 °C

2: caesium carbonate; copper(l) iodide; N,N-dimethylethylenediamine / 1,4-dioxane / 150 °C

With copper(l) iodide; caesium carbonate; N,N-dimethylethylenediamine; trifluoroacetic acid; In 1,4-dioxane;