2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

Base Information

Chemical Name:2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester
CAS No.:143006-19-3
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

Synonyms:2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

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Chemical Property of 2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

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Technology Process of 2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

There total 11 articles about 2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 143006-17-1
((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-(diethoxy-phosphoryl)-acetic acid benzyl ester

: 143006-19-3
2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

Guidance literature:: With sodium hydrogencarbonate; In methanol; water; ethyl acetate; for 0.166667h; Ambient temperature;
DOI:10.1021/jo00046a030

Reference yield:

: 54214-74-3
1-acetoxy-5-hexen-2-one ethylene glycol ketal

: 143006-19-3
2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / NaIO₄, OsCl₃ / H₂O; 2-methyl-propan-2-ol / 0.5 h / Ambient temperature

2: MgSO₄ / diethyl ether / 0.67 h / Ambient temperature

3: 32 percent / CH₂Cl₂ / 44 h / Irradiation

4: 67 percent / 0.2N HCl / methanol / 1.5 h / Ambient temperature

5: 74 percent / LiBF₄ / acetonitrile; H₂O / 12 h / Heating

6: 77 percent / NaHCO₃ / methanol; ethyl acetate; H₂O / 0.17 h / Ambient temperature

With hydrogenchloride; sodium periodate; lithium tetrafluoroborate; osmium (III) chloride; sodium hydrogencarbonate; magnesium sulfate; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00046a030

Reference yield:

: 54214-75-4
5-acetoxy-4-oxopentanal-4-ethylene glycol ketal

: 143006-19-3
2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: MgSO₄ / diethyl ether / 0.67 h / Ambient temperature

2: 32 percent / CH₂Cl₂ / 44 h / Irradiation

3: 67 percent / 0.2N HCl / methanol / 1.5 h / Ambient temperature

4: 74 percent / LiBF₄ / acetonitrile; H₂O / 12 h / Heating

5: 77 percent / NaHCO₃ / methanol; ethyl acetate; H₂O / 0.17 h / Ambient temperature

With hydrogenchloride; lithium tetrafluoroborate; sodium hydrogencarbonate; magnesium sulfate; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo00046a030