(Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

Base Information

Chemical Name:(Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate
CAS No.:1564245-61-9
Molecular Formula:C₁₆H₂₀BrNO₄
Molecular Weight:370.243
Hs Code.:

Synonyms:(Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

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Chemical Property of (Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

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Technology Process of (Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

There total 1 articles about (Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1611-92-3,188813-04-9
3-bromo-5-methylbenzaldehyde

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 1564245-61-9
(Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

: (E)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;
DOI:10.1021/ol500219e

Reference yield: 51.0%

: 1564245-61-9
(Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate

: 73183-34-3
bis(pinacol)diborane

: 1564245-85-7
(2S,3R)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate

: 1564245-86-8
(2R,3R)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate

Guidance literature:: bis(pinacol)diborane; With (S,Sp)-ip-FOXAP; copper(l) chloride; sodium t-butanolate; In toluene; at 20 ℃; for 0.5h; Schlenk technique; Molecular sieve; Inert atmosphere;

(Z)-methyl 3-(3-bromo-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate; With methanol; In toluene; at 20 ℃; for 16h; enantioselective reaction; Schlenk technique; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol500219e