1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate
CAS No.:1355024-92-8
Molecular Formula:C₂₁H₂₇N₃O₆
Molecular Weight:417.462
Hs Code.:

Synonyms:1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

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Chemical Property of 1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

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Technology Process of 1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

There total 3 articles about 1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 7677-24-9
trimethylsilyl cyanide

: 1355024-91-7
1-tert-butyl 2-methyl 4-(3,4-dimethoxybenzyl)-5-hydroxy-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

: 1355024-92-8
1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ol203364b

Reference yield:

: 5763-61-1
3,4-dimethoxybenzylamine

: 1355024-92-8
1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / 5 h / -78 °C / Inert atmosphere

With boron trifluoride diethyl etherate; potassium carbonate; In dichloromethane; acetonitrile; 1: Michael addition;
DOI:10.1021/ol203364b

Reference yield:

: 943818-65-3
4-(tert-butoxycarbonyl)-3-methoxycarbonyl-4H-[1,4]oxazine

: 1355024-92-8
1-tert-butyl 2-methyl 5-cyano-4-(3,4-dimethoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / 5 h / -78 °C / Inert atmosphere

With boron trifluoride diethyl etherate; potassium carbonate; In dichloromethane; acetonitrile; 1: Michael addition;
DOI:10.1021/ol203364b