(2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

Base Information

Chemical Name:(2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid
CAS No.:1073544-33-8
Molecular Formula:C₂₉H₃₃FO₄
Molecular Weight:464.577
Hs Code.:

Synonyms:(2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

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Chemical Property of (2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

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Technology Process of (2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

There total 10 articles about (2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 1073544-33-8
(2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dimethyl sulfoxide / 2.5 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-heptane; ethylbenzene / 0.5 h / -78 °C

2.2: 16.33 h / -78 - 20 °C

3.1: hydrogen / palladium on activated carbon / methanol / 20 °C

4.1: Resolution of racemate

5.1: caesium carbonate / dimethyl sulfoxide / 16 h / 20 °C

6.1: lithium hydroxide; water / dimethyl sulfoxide / 16 h / 20 °C

With lithium hydroxide; water; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated carbon; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-heptane; ethylbenzene; dimethyl sulfoxide;

Reference yield:

: C₃₀H₃₅FO₄

: 1073544-33-8
(2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

Guidance literature:: With lithium hydroxide; water; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

: 1073546-43-6
methyl 2-((4-((phenylmethyl)oxy)phenyl)methyl)butanoate

: 1073544-33-8
(2R)-2-((4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)methyl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated carbon / methanol / 20 °C

2: Resolution of racemate

3: caesium carbonate / dimethyl sulfoxide / 16 h / 20 °C

4: lithium hydroxide; water / dimethyl sulfoxide / 16 h / 20 °C

With lithium hydroxide; water; hydrogen; caesium carbonate; palladium on activated carbon; In methanol; dimethyl sulfoxide;