ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate

Base Information

• Chemical Name: ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate
• CAS No.: 186962-33-4
• Molecular Formula: C₁₅H₁₇NO₅
• Molecular Weight: 291.304
• Mol file: 186962-33-4.mol

Synonyms:ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate

Chemical Property of ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate

There total 1 articles about ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

O-benzyl carbamate (621-84-1) + 2-ethoxymethylene-3-oxobutanoic acid ethyl ester (3788-94-1) → ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate (186962-33-4)

Guidance literature:

at 170 ℃; for 2h;

DOI:10.1021/ol901544q

Reference yield:

ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate (186962-33-4) + propionaldehyde (123-38-6) → C18H23NO6

Guidance literature:

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid; In water; acetonitrile; at 20 ℃;

DOI:10.1021/ol901544q

Reference yield:

2-chloropropanal (683-50-1) + ethyl (E)-2-((benzyloxycarbonylamino)methylene)-3-oxobutanoate (186962-33-4) → C18H21NO6 + C18H21NO6 (1186130-47-1)

Guidance literature:

With BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; triethylamine; In tetrachloromethane; ethyl acetate; at 20 ℃; for 50h; optical yield given as %de; enantioselective reaction;

DOI:10.1021/ol901544q

upstream raw materials:

O-benzyl carbamate

2-ethoxymethylene-3-oxobutanoic acid ethyl ester

Downstream raw materials:

C₁₈H₂₁NO₆