2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine

Base Information

• Chemical Name: 2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine
• CAS No.: 160436-47-5
• Molecular Formula: C₁₇H₁₂ClF₃N₂O₃
• Molecular Weight: 384.742
• Mol file: 160436-47-5.mol

Synonyms:2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine

Chemical Property of 2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine

There total 1 articles about 2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

ethyl bromoacetate (105-36-2) + 6-(4-chlorophenyl)-3-cyano-4-trifluoromethyl-2(1H)-pyridone (147381-62-2) → 2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine (160436-47-5)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; at 60 ℃; for 4h;

DOI:10.1016/0022-1139(94)03079-0

Reference yield: 76.8%

2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine (160436-47-5) → 2-carbethoxy-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro-<2,3-b>-pyridine (160436-51-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 3h;

DOI:10.1016/0022-1139(94)03079-0

Reference yield:

2-O-ethylacetoxy-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine (160436-47-5) → 2-carbohydrazide-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro-<2,3-b>-pyridine (160436-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.8 percent / K₂CO₃ / dimethylformamide / 3 h / 110 - 120 °C

2: 91.8 percent / N₂H₄*H₂O / aq. ethanol / 2 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0022-1139(94)03079-0

upstream raw materials:

ethyl bromoacetate

6-(4-chlorophenyl)-3-cyano-4-trifluoromethyl-2(1H)-pyridone

Downstream raw materials:

2-carbethoxy-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro-<2,3-b>-pyridine

2-carbohydrazide-3-amino-4-trifluoromethyl-6-p-chlorophenylfuro-<2,3-b>-pyridine