(1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

Base Information

Chemical Name:(1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide
CAS No.:1287745-10-1
Molecular Formula:C₂₇H₄₀ClN₃O₃
Molecular Weight:490.086
Hs Code.:

Synonyms:(1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

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Chemical Property of (1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

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Technology Process of (1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

There total 3 articles about (1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.8%

: 946594-83-8
(R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-oxocyclopentanecarboxamide

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1287745-10-1
(1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

Guidance literature:: With ammonia; at 20 ℃; for 16h;

Reference yield:

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

: 1287745-10-1
(1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 3 h / 20 °C

2: ammonia / 16 h / 20 °C

With ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran;

Reference yield:

: 13012-38-9
(1R)-3-oxocyclopentane-1-carboxylic acid

: 1287745-10-1
(1R)-3-allyl-3-amino-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 3 h / 20 °C

2: ammonia / 16 h / 20 °C

With ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran;