5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide
CAS No.:1373844-71-3
Molecular Formula:C₂₂H₂₄N₄O₃S
Molecular Weight:424.524
Hs Code.:

Synonyms:5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

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Chemical Property of 5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

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Technology Process of 5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

There total 10 articles about 5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1373839-55-4
2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2H-indazole-3-carboxamide

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1373844-71-3
5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

Guidance literature:: With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 95 ℃; for 5h; Inert atmosphere;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373844-71-3
5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice

2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

4.1: acetic acid / 60 °C

4.2: 0.08 h / 60 °C

5.1: phosphorus trichloride / chloroform / 1 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

7.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

8.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

10.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 5 h / 95 °C / Inert atmosphere

With pyridine; potassium phosphate; sulfuric acid; water; nitric acid; iron; sodium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene; 3.1: Suzuki Coupling;

Reference yield:

: 20357-20-4
5-bromo-2-nitrobenzaldehyde

: 1373844-71-3
5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

3.1: acetic acid / 60 °C

3.2: 0.08 h / 60 °C

4.1: phosphorus trichloride / chloroform / 1 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

6.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

7.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

9.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 5 h / 95 °C / Inert atmosphere

With pyridine; potassium phosphate; sulfuric acid; water; nitric acid; iron; sodium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene; 2.1: Suzuki Coupling;