(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

Base Information

Chemical Name:(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one
CAS No.:197517-56-9
Molecular Formula:C₁₈H₂₅IO₃
Molecular Weight:416.299
Hs Code.:

Synonyms:(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

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Chemical Property of (R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

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Technology Process of (R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

There total 7 articles about (R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 197517-54-7
(E)-(8S,9R)-10-Benzyloxy-8-tert-butoxy-9-methyl-dec-4-en-3-one

: 197517-56-9
(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

Guidance literature:: With iodine; sodium hydrogencarbonate; In acetonitrile; at 5 ℃;
DOI:10.1055/s-1997-1547

Reference yield:

: 197517-45-6
(2R,3R)-4-benzyloxy-1,2-epoxy-3-methylbutane

: 197517-56-9
(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / CuI / diethyl ether

2: Amberlyst H-15 / hexane

3: 86 percent / OsO₄, NaIO₄ / dioxane; H₂O

4: 82 percent / NaH / tetrahydrofuran / -20 - 0 °C

5: 92 percent / I₂, NaHCO₃ / acetonitrile / 5 °C

With sodium periodate; osmium(VIII) oxide; Amberlyst H-15; iodine; sodium hydride; sodium hydrogencarbonate; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; acetonitrile;
DOI:10.1055/s-1997-1547

Reference yield:

: 155489-00-2
(2R,3R)-4-benzyloxy-3-methylbutan-1,2-diol

: 197517-56-9
(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-1-iodo-butan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 30percent HBr/AcOH; 2.) KOH / 1.) Et₂O; 2.) MeOH, THF

2: 99 percent / CuI / diethyl ether

3: Amberlyst H-15 / hexane

4: 86 percent / OsO₄, NaIO₄ / dioxane; H₂O

5: 82 percent / NaH / tetrahydrofuran / -20 - 0 °C

6: 92 percent / I₂, NaHCO₃ / acetonitrile / 5 °C

With potassium hydroxide; sodium periodate; osmium(VIII) oxide; Amberlyst H-15; hydrogen bromide; iodine; sodium hydride; sodium hydrogencarbonate; acetic acid; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; acetonitrile;
DOI:10.1055/s-1997-1547