2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl)-N-ethylacetamide

Base Information

• Chemical Name: 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl)-N-ethylacetamide
• CAS No.: 1388893-64-8
• Molecular Formula: C₂₁H₃₁N₅OS
• Molecular Weight: 401.576

Synonyms:2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl)-N-ethylacetamide

Chemical Property of 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl)-N-ethylacetamide

Chemical Property:

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Technology Process of 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl)-N-ethylacetamide

There total 8 articles about 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl)-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

C20H28N4O2S (1388893-60-4) + ethylamine (75-04-7,85404-22-4) → 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-ethylacetamide (1388893-64-8)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃;

Reference yield:

C12H11ClN2O2S (1019014-42-6) → 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-ethylacetamide (1388893-64-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 55 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.2: 2 h

3.1: thionyl chloride / 20 °C

4.1: dimethyl sulfoxide / 5 h / 70 °C

5.1: thionyl chloride / Cooling with ice

5.2: 16 h / 70 °C

6.1: water; tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

C18H25ClN4S (1388893-58-0) → 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-ethylacetamide (1388893-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 5 h / 70 °C

2.1: thionyl chloride / Cooling with ice

2.2: 16 h / 70 °C

3.1: water; tetrahydrofuran / 20 °C

With thionyl chloride; In tetrahydrofuran; water; dimethyl sulfoxide;

upstream raw materials:

C₂₀H₂₈N₄O₂S

ethylamine

2-ethoxycarbonyl-1-cyclopentanone

ethyl 12-hydroxy-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraene-3-carboxylate

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