3-(phenylethynyl)-5-methoxypyridine

Base Information

• Chemical Name: 3-(phenylethynyl)-5-methoxypyridine
• CAS No.: 866684-37-9
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.247
• Mol file: 866684-37-9.mol

Synonyms:3-(phenylethynyl)-5-methoxypyridine

Chemical Property of 3-(phenylethynyl)-5-methoxypyridine

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(phenylethynyl)-5-methoxypyridine

There total 2 articles about 3-(phenylethynyl)-5-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-bromo-5-methoxypyridine (50720-12-2) + phenylacetylene (536-74-3) → 3-(phenylethynyl)-5-methoxypyridine (866684-37-9)

Guidance literature:

3-bromo-5-methoxypyridine; With bis(η3-allyl-μ-chloropalladium(II)); 1-n-butyl-3-methylimidazolium tetrafluoroborate; triphenylphosphine; at 60 ℃; Inert atmosphere;

phenylacetylene; With pyrrolidine; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0031-1289861

Reference yield: 75.0%

3-bromo-5-methoxypyridine (50720-12-2) + phenylpropyolic acid (637-44-5) → 3-(phenylethynyl)-5-methoxypyridine (866684-37-9)

Guidance literature:

With C₁₈H₁₉N₃O₂Pd; caesium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 1h;

DOI:10.1002/adsc.201200876

Reference yield: 4.0%

3-(phenylethynyl)-5-methoxypyridine (866684-37-9) → 3-hydroxy-5-phenylethynylpyridine (866684-39-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃;

upstream raw materials:

3-bromo-5-methoxypyridine

phenylacetylene

phenylpropyolic acid

Downstream raw materials:

3-hydroxy-5-phenylethynylpyridine