1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, (1S-exo)- (9CI)

Base Information

Chemical Name:1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, (1S-exo)- (9CI)
CAS No.:765868-79-9
Molecular Formula:C₇H₁₀ClNO
Molecular Weight:159.615
Hs Code.:
Mol file:765868-79-9.mol

Synonyms:1-Azabicyclo[2.2.1]heptane-3-carbonylchloride, (1S-exo)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, (1S-exo)- (9CI)

Chemical Property:

Purity/Quality:

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Technology Process of 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, (1S-exo)- (9CI)

There total 14 articles about 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, (1S-exo)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 130513-77-8,730925-03-8,765868-79-9,193674-17-8
(1S,3S,4S)-1-Aza-bicyclo[2.2.1]heptane-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄ / toluene; dimethylformamide / 1.5 h / -20 - 35 °C

2: 5 M HCl / 0.5 h / Heating

3: H₂, AcOH / 10percent Rh/C / ethanol / 24 h / 90 °C / 51714.8 Torr

4: K₂CO₃ / ethanol / 0.75 h / Ambient temperature

5: HBr (gas) / 216 h / Ambient temperature

6: aq. K₂CO₃

7: H₂, AcOH / 10percent Pd/C / ethanol / 40 °C / 760 Torr

8: 8 M HCl / 2 h / Heating

9: SOCl₂ / 4.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydrogen bromide; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; Rh on carbon; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00113a009

Reference yield:

: 3393-45-1
5,6-dihydro-pyran-2-one

: 130513-77-8,730925-03-8,765868-79-9,193674-17-8
(1R,3S,4R)-1-Aza-bicyclo[2.2.1]heptane-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) HBr gas, 2.) aq. K₂CO₃, 3.) H₂ / 3.) 10percent Pd/C

3: 5 N HCl / 4 h / Heating

4: SOCl₂ / 0.25 h

With hydrogenchloride; thionyl chloride; hydrogen bromide; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1021/jm00091a007

Reference yield:

: 5657-52-3
1,3-dihydrofuro<3,4-c>pyridin-3-one

: 130513-77-8,730925-03-8,765868-79-9,193674-17-8
(1S,3S,4S)-1-Aza-bicyclo[2.2.1]heptane-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: H₂, AcOH / 10percent Rh/C / ethanol / 24 h / 90 °C / 51714.8 Torr

2: K₂CO₃ / ethanol / 0.75 h / Ambient temperature

3: HBr (gas) / 216 h / Ambient temperature

4: aq. K₂CO₃

5: H₂, AcOH / 10percent Pd/C / ethanol / 40 °C / 760 Torr

6: 8 M HCl / 2 h / Heating

7: SOCl₂ / 4.5 h / Heating

With hydrogenchloride; thionyl chloride; hydrogen bromide; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; Rh on carbon; In ethanol;
DOI:10.1021/jm00113a009