3393-45-1 Usage
Uses
Used in Pharmaceutical Industry:
5,6-Dihydro-2H-pyran-2-one is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 5,6-dihydro-2H-pyran-2-one serves as a versatile synthetic intermediate for the preparation of a wide range of organic compounds. Its ability to undergo various chemical reactions, such as nucleophilic addition, electrophilic substitution, and rearrangement reactions, makes it a useful component in the synthesis of complex organic molecules.
Used in the Preparation of Specific Compounds:
5,6-Dihydro-2H-pyran-2-one has been specifically used in the preparation of the compound (1aR,5aR,5bS,6S,7S)-6,7-di-tert-butoxy-5-oxo-pyrrolidino[1,2-b]isoxazolidino[4,5-c]tetrahydropyran 4-(phenyl)tetrahydro-2H-pyran-2-one. This complex molecule may have potential applications in various fields, such as pharmaceuticals, materials science, or as a precursor for further chemical transformations.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 1647, 1984 DOI: 10.1021/jo00183a030Tetrahedron Letters, 25, p. 4783, 1984 DOI: 10.1016/S0040-4039(01)81518-5
Check Digit Verification of cas no
The CAS Registry Mumber 3393-45-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,9 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3393-45:
(6*3)+(5*3)+(4*9)+(3*3)+(2*4)+(1*5)=91
91 % 10 = 1
So 3393-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H6O2/c6-5-3-1-2-4-7-5/h1,3H,2,4H2
3393-45-1Relevant academic research and scientific papers
Catalytic Allylic Oxidation of Cyclic Enamides and 3,4-Dihydro-2H-Pyrans by TBHP
Yu, Yang,Humeidi, Ranad,Alleyn, James R.,Doyle, Michael P.
, p. 8506 - 8513 (2017/08/23)
Allylic oxidation of heteroatom substituted cyclic alkenes by tert-butyl hydroperoxide (70% TBHP in water) using catalytic dirhodium caprolactamate [Rh2(cap)4] forms enone products with a variety of 2-substituted cyclic enamides and 3,4-dihyro-2H-pyrans. These reactions occur under mild reaction conditions, are operationally convenient to execute, and are effective for product formation with as low as 0.25 mol% catalyst loading. With heteroatom stabilization of the intermediate allylic free radical two sites for oxidative product formation are possible, and the selectivity of the oxidative process varies with the heteroatom when R = H. Cyclic enamides produce 4-piperidones in good yields when R = alkyl or aryl, but oxidation of 2H-pyrans also gives alkyl cleavage products. Alternative catalysts for TBHP oxidations show comparable selectivities but give lower product yields.
Tandem cross enyne metathesis (CEYM)-intramolecular Diels-Alder reaction (IMDAR). An easy entry to linear bicyclic scaffolds
Miró, Javier,Sánchez-Roselló, María,Sanz, álvaro,Rabasa, Fernando,Del Pozo, Carlos,Fustero, Santos
supporting information, p. 1486 - 1493 (2016/04/09)
A new tandem cross enyne metathesis (CEYM)-intramolecular Diels-Alder reaction (IMDAR) has been carried out. It involves conjugated ketones, esters or amides bearing a remote olefin and aromatic alkynes as the starting materials. The overall process enabl
