1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Base Information

Chemical Name:1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol
CAS No.:1222135-24-1
Molecular Formula:C₂₄H₂₆N₂O₂
Molecular Weight:374.483
Hs Code.:

Synonyms:1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

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Chemical Property of 1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

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Technology Process of 1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

There total 10 articles about 1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1222139-27-6
1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

: 1222135-24-1
1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Guidance literature:: 1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol; With water; trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In water;

Reference yield:

: 186593-31-7
(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1222135-24-1
1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 27 h / 90 °C / Inert atmosphere

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine; cesium fluoride / 1-methyl-pyrrolidin-2-one; hexane / 3 h / 80 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane; water / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; water; toluene;

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 1222135-24-1
1-[3-[5-[(2(S)-azetidinyl)methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

2.1: hydrogenchloride; triethylamine; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran; hexane / 3 h / -40 °C / Inert atmosphere

3.2: 2 h / -20 - -5 °C

4.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine; cesium fluoride / 1-methyl-pyrrolidin-2-one; hexane / 3 h / 80 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane; water / Inert atmosphere

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; borane-THF; tri-tert-butyl phosphine; isopropylmagnesium chloride; triethylamine; p-toluenesulfonyl chloride; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; water;