1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Base Information

Chemical Name:1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol
CAS No.:1222139-27-6
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

Synonyms:1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Suppliers and Price of 1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

There total 8 articles about 1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1222139-25-4
1-(3-bromophenyl)-3-phenyl-2(S)-propanol

: 213766-21-3
tert-butyl (2S)-2-({[5-(trimethylstannyl)pyridin-3-yl]oxy}methyl)azetidine-1-carboxylate

: 1222139-27-6
1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Guidance literature:: With tri-tert-butyl phosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; cesium fluoride; In 1-methyl-pyrrolidin-2-one; hexane; at 20 - 80 ℃;

Reference yield:

: 186593-31-7
(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1222139-27-6
1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 27 h / 90 °C / Inert atmosphere

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine; cesium fluoride / 1-methyl-pyrrolidin-2-one; hexane / 3 h / 80 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride; In 1-methyl-pyrrolidin-2-one; hexane; toluene;

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 1222139-27-6
1-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-3-phenyl-2(S)-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

2.1: hydrogenchloride; triethylamine; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran; hexane / 3 h / -40 °C / Inert atmosphere

3.2: 2 h / -20 - -5 °C

4.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine; cesium fluoride / 1-methyl-pyrrolidin-2-one; hexane / 3 h / 80 °C / Inert atmosphere

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; borane-THF; tri-tert-butyl phosphine; isopropylmagnesium chloride; triethylamine; p-toluenesulfonyl chloride; cesium fluoride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane;