141699-57-2

Basic information

• Product Name: 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE
• Synonyms: 1-(tert-Butoxycarbonyl)pyrrolidin-3-yl methanesulfonate;1-BOC-3-METHANESULFONYLOXYPYRROLIDINE;3-METHANESULFONYLOXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected;(R)-3-(Methylsulphonyloxy)pyrrolidine
• CAS NO: 141699-57-2
• Molecular Formula: C₁₀H₁₉NO₅S
• Molecular Weight: 265.33
• Mol File: 141699-57-2.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 392.882 °C at 760 mmHg
• Flash Point: 191.408 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 2.22E-06mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: 2-8°C
• PKA: -3.65±0.40(Predicted)
• CAS DataBase Reference: 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE(141699-57-2)
• EPA Substance Registry System: 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE(141699-57-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 141699-57-2(Hazardous Substances Data)

Usage

General Description

1-BOC-3-Methanesulfonyloxypyrrolidine is a chemical compound consisting of a pyrrolidine ring with a methanesulfonyloxy group and a tert-butoxycarbonyl (BOC) protecting group. It is commonly used as a reagent in organic synthesis and chemical reactions, serving as a versatile building block for the construction of various molecules. 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE is known for its ability to facilitate the formation of new carbon-carbon bonds and has applications in medicinal chemistry, pharmaceutical manufacturing, and agrochemical development. Additionally, 1-BOC-3-Methanesulfonyloxypyrrolidine is valued for its stability and compatibility with a wide range of reaction conditions, making it a valuable tool in the synthesis of complex organic compounds.

InChI:InChI=1/C10H19NO5S/c1-10(2,3)15-9(12)11-6-5-8(7-11)16-17(4,13)14/h8H,5-7H2,1-4H3

Upstream product

• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 124-63-0 methanesulfonyl chloride 
• 111810-68-5 3-hydroxypyrrolidine hydrochloride 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 

Downstream Products

• 197525-84-1 3-[4-amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 950648-92-7 tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate 
• 1428253-07-9 tert-butyl 3-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl)pyrrolidine-1-carboxylate 
• 1428253-09-1 tert-butyl 3-(2-(1-(6-amino-5-cyanopyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)pyrrolidine-1-carboxylate 
• 1428253-08-0 tert-butyl 3-(2-(1-(6-amino-5-carbamoylpyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)pyrrolidine-1-carboxylate 
• 1428253-06-8 benzyl 4-(1-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate 
• 99520-88-4 pyrrolidin-3-yl methanesulfonate 
• 476493-40-0 3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester 
• 270912-72-6 tert-butyl 3-(aminomethyl)pyrrolidine-1-carboxylate 
• 1029413-53-3 tert-butyl 3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate 
• 186550-13-0 3-amino-1-(t-butoxycarbonyl)pyrrolidine 
• 609789-06-2 1-(tert-butoxycarbonyl)-3-(4-cyanophenylamino)pyrrolidine 
• 1932525-90-0 tert-butyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

ATF6 MODULATORS AND USES THEREOF

Compounds (1-2) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer. (Formula (1-2))

Compound used as RET kinase inhibitor and application thereof

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Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors

Never in mitosis (NIMA) related kinase 2 (Nek2) is involved in multiple cellular processes such as cell cycle checkpoint regulation, cell division, DNA damage response and cell apoptosis. Nek2 has been reported to be overexpressed in various tumors and correlated with poor prognosis. Herein, a series of imidazo[1,2-a] pyridines Nek2 inhibitors were designed, synthesized, and their biological activities were investigated. Besides, structure activity relationship analysis of these compounds were performed in the MGC-803 cell. The screening results are promising, and compound 28e shows good proliferation inhibitory activity with an IC50 of 38 nM. The results would be helpful to design and develop more effective Nek2 inhibitors for the treatment of gastric cancer.