2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

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Chemical Name:2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid
CAS No.:1313377-82-0
Molecular Formula:C₂₀H₂₃N₃O₃
Molecular Weight:353.421
Hs Code.:

Synonyms:2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

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Chemical Property of 2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

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Technology Process of 2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

There total 6 articles about 2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1313377-81-9
2-[2-tert-butyl-7-(2-methoxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

: 1313377-82-0
2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

Guidance literature:: With pyridine; lithium iodide; at 170 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 95740-49-1
1-bromo-2-methoxy-4-methylbenzene

: 1313377-82-0
2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / pentane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 140 °C / Microwave irradiation

3.1: sodium hydroxide / methanol / 24 h / 75 °C

4.1: pyridine; lithium iodide / 1.5 h / 170 °C / Microwave irradiation

With pyridine; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; pentane; 2.1: Suzuki Coupling;

Reference yield:

: 39538-68-6
2-methoxy-4-methylaniline

: 1313377-82-0
2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.33 h / 65 °C / Inert atmosphere

2.1: tert.-butyl lithium / pentane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 140 °C / Microwave irradiation

4.1: sodium hydroxide / methanol / 24 h / 75 °C

5.1: pyridine; lithium iodide / 1.5 h / 170 °C / Microwave irradiation

With pyridine; tert.-butylnitrite; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(ll) bromide; lithium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetonitrile; pentane; 3.1: Suzuki Coupling;