(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Base Information

Chemical Name:(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
CAS No.:1262870-14-3
Molecular Formula:C₃₇H₃₇N₃O₅
Molecular Weight:603.718
Hs Code.:

Synonyms:(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

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Chemical Property of (4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

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Technology Process of (4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

There total 8 articles about (4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1262870-13-2
(4bS,8aS,9S)-benzyl 2-amino-3-(benzyloxy)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

: 88-73-3
2-Chloronitrobenzene

: 1262870-14-3
(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Guidance literature:: With sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃;

Reference yield:

: (+)-3-hydroxymorphinan hydrobromide

: 1262870-14-3
(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / 1,4-dioxane; water / 0.5 h / 0 - 20 °C

2: nitric acid; formic acid / water / 0 - 20 °C

3: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

6: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

With formic acid; nitric acid; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1262870-04-1
(4bS,8aS,9S)-benzyl 3-hydroxy-2-nitro-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

: 1262870-14-3
(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

2: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

3: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

With potassium carbonate; hydrazine hydrate; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; water; N,N-dimethyl-formamide; toluene;