(+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

Base Information

Chemical Name:(+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan
CAS No.:1262870-22-3
Molecular Formula:C₄₂H₄₅N₃O₇
Molecular Weight:703.835
Hs Code.:

Synonyms:(+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

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Chemical Property of (+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

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Technology Process of (+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

There total 7 articles about (+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1262870-14-3
(4bS,8aS,9S)-benzyl 3-(benzyloxy)-2-((2-nitrophenyl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

: 1262870-22-3
(+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

Guidance literature:: With dmap; In tetrahydrofuran; at 70 ℃;

Reference yield:

: 15676-23-0
(+)-3-Hydroxymorphinan

: 1262870-22-3
(+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; formic acid / water / 0 - 20 °C

2: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C

4: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

5: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

6: dmap / tetrahydrofuran / 70 °C

With dmap; formic acid; nitric acid; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: (+)-3-hydroxymorphinan hydrobromide

: 1262870-22-3
(+)-3-benzyloxy-2-(2-nitrophenyl(tert-butyloxylcarbonyl)amino)-N-(benzyloxycarbonyl)morphinan

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / 1,4-dioxane; water / 0.5 h / 0 - 20 °C

2: nitric acid; formic acid / water / 0 - 20 °C

3: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

6: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

7: dmap / tetrahydrofuran / 70 °C

With dmap; formic acid; nitric acid; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;