2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

Base Information

Chemical Name:2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid
CAS No.:1436855-54-7
Molecular Formula:C₁₈H₁₇ClN₂O₃
Molecular Weight:344.798
Hs Code.:

Synonyms:2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

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Chemical Property of 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

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Technology Process of 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

There total 11 articles about 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1436855-53-6
2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

: 1436855-54-7
2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

Guidance literature:: With hydrogenchloride; In water; at 100 ℃; for 18h;

Reference yield:

: 1436855-50-3
(4-chloro-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-54-7
2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

3: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

4: hydrogenchloride / water / 18 h / 100 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; zinc(II) iodide; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 1436855-51-4
(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-54-7
2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

2: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

3: hydrogenchloride / water / 18 h / 100 °C

With hydrogenchloride; sulfur trioxide pyridine complex; triethylamine; zinc(II) iodide; In dichloromethane; water; dimethyl sulfoxide;