2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Base Information

Chemical Name:2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile
CAS No.:1436855-53-6
Molecular Formula:C₂₉H₃₂ClN₃O₂Si
Molecular Weight:518.13
Hs Code.:

Synonyms:2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

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Chemical Property of 2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

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Technology Process of 2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

There total 12 articles about 2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1436855-52-5
4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridine-5-carboaldehyde

: 1436855-53-6
2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: With zinc(II) iodide; In dichloromethane; at 0 - 25 ℃; for 4h; Inert atmosphere;

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 1436855-53-6
2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: cyclohexane / 2 h / Reflux; Dean-Stark

1.2: 2 h / 0 °C / Reflux; Dean-Stark

2.1: toluene-4-sulfonic acid / o-xylene / 18 h / Reflux

3.1: sodium ethanolate / ethanol / 18 h / Reflux

4.1: trichlorophosphate / 4 h / 60 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C / Inert atmosphere

6.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

7.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

8.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium ethanolate; sulfur trioxide pyridine complex; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; zinc(II) iodide; trichlorophosphate; In ethanol; dichloromethane; o-xylene; cyclohexane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 6.1: |Suzuki Coupling;

Reference yield:

: 1436855-50-3
(4-chloro-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-53-6
2-(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

3: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; zinc(II) iodide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Suzuki Coupling;