N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide

Base Information

Chemical Name:N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide
CAS No.:77726-01-3
Molecular Formula:C14H21 N3 O2
Molecular Weight:0
Hs Code.:2933599090
DSSTox Substance ID:DTXSID70512261
Wikidata:Q82371430
Mol file:77726-01-3.mol

Synonyms:77726-01-3;DTXSID70512261;N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide

Suppliers and Price of N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide

Chemical Property:

PSA：59.30000
LogP:1.62330
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:263.16337692
Heavy Atom Count:19
Complexity:303

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=CC(=C(C=C1)O)CN2CCN(CC2)C

Technology Process of N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide

There total 1 articles about N-{4-Hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 109-01-3
1-methyl-piperazine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 103-90-2,8055-08-1
4-acetaminophenol

: 77726-01-3
N-[4-Hydroxy-3-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acetamide

Guidance literature:

Reference yield:

: 77726-01-3
N-[4-Hydroxy-3-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acetamide

: 76226-58-9
4-amino-2-((4-methylpiperazin-1-yl)methyl)phenol

Guidance literature:: With hydrogenchloride; for 3h; Heating;
DOI:10.1211/0022357011777765

Reference yield:

: 77726-01-3
N-[4-Hydroxy-3-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acetamide

: 500565-15-1
4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 1.5 h / 90 °C / Inert atmosphere

2: ethanol; water / 12 h / 90 °C / Inert atmosphere

With hydrogenchloride; In ethanol; water;
DOI:10.1021/acs.jmedchem.9b00326