3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

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Chemical Name:3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide
CAS No.:1140924-29-3
Molecular Formula:C₁₇H₃₀N₂O₆SSi
Molecular Weight:418.587
Hs Code.:

Synonyms:3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

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Chemical Property of 3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

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Technology Process of 3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

There total 4 articles about 3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1265501-11-8
tert-butyl 3-(4-hydroxy-2-methoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

: 106018-85-3
2-trimethylsilanyl-ethanesulfonyl chloride

: 1140924-29-3
3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

Guidance literature:: tert-butyl 3-(4-hydroxy-2-methoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate; With trifluoroacetic acid; In dichloromethane; for 4h;

2-trimethylsilanyl-ethanesulfonyl chloride; With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1021/jo102327e

Reference yield:

: C₂₃H₃₈N₂O₇SSi

: 1140924-29-3
3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

Guidance literature:: C₂₃H₃₈N₂O₇SSi; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 22 ℃; for 1h;

With hydrogenchloride; In dichloromethane; water;
DOI:10.1021/jo900012z

Reference yield:

: 1206547-02-5
C₂₁H₃₁NO₈

: 1140924-29-3
3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2-(trimethylsilyl)ethylsulfonamino)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydrochloride monohydrate / tetrahydrofuran; water / 14 h / 20 °C

1.2: pH 1

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h

3.2: 6 h / 20 °C

With lithium hydrochloride monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo102327e