3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

Base Information

Chemical Name:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile
CAS No.:1352609-65-4
Molecular Formula:C₂₆H₂₅N₉
Molecular Weight:463.545
Hs Code.:

Synonyms:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

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Chemical Property of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

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Technology Process of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

There total 11 articles about 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₃N₉

: 1352609-65-4
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1352609-65-4
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 3.5 h / 220 °C / Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 13 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / Inert atmosphere

5.1: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

6.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 93213-75-3
2-(bromomethyl)-3-nitrobenzonitrile

: 1352609-65-4
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / Inert atmosphere

3.1: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022