3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

Base Information

Chemical Name:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride
CAS No.:1352610-56-0
Molecular Formula:C₂₆H₂₅N₉*ClH
Molecular Weight:500.006
Hs Code.:

3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

Synonyms:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

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Chemical Property of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

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Technology Process of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

There total 12 articles about 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1352609-65-4
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile

: 1352610-56-0
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 71516-35-3
2-methyl-3-nitrobenzonitrile

: 1352610-56-0
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 13 h / Inert atmosphere; Reflux

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / Inert atmosphere

4.1: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

5.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / dichloromethane; diethyl ether / 0.25 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1352610-56-0
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-2-((dimethylamino)methyl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 3.5 h / 220 °C / Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 13 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / Inert atmosphere

5.1: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

6.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride / dichloromethane; diethyl ether / 0.25 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022