(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Base Information

Chemical Name:(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone
CAS No.:736180-10-2
Molecular Formula:C₂₀H₂₁NO₄
Molecular Weight:339.391
Hs Code.:

Synonyms:(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Suppliers and Price of (-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

There total 3 articles about (-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 736180-09-9
(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

: 736180-10-2
(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 2h;
DOI:10.1039/b404325a

Reference yield:

: 591-51-5
phenyllithium

: 736180-10-2
(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / diethyl ether; cyclohexane / 0.17 h / -78 - -15 °C

1.2: 42 percent / diethyl ether; cyclohexane / 2 h / -15 °C

2.1: 52 percent / TFA / CHCl₃ / 2 h / 20 °C

With copper(l) iodide; trifluoroacetic acid; In diethyl ether; chloroform; cyclohexane;
DOI:10.1039/b404325a

Reference yield:

: (-)-(2S,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]non-7-ene

: 736180-10-2
(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / diethyl ether; cyclohexane / 0.17 h / -78 - -15 °C

1.2: 42 percent / diethyl ether; cyclohexane / 2 h / -15 °C

2.1: 52 percent / TFA / CHCl₃ / 2 h / 20 °C

With copper(l) iodide; trifluoroacetic acid; In diethyl ether; chloroform; cyclohexane;
DOI:10.1039/b404325a