(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

Base Information

Chemical Name:(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane
CAS No.:736180-09-9
Molecular Formula:C₂₈H₂₇NO₄
Molecular Weight:441.527
Hs Code.:

Synonyms:(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

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Chemical Property of (-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

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Technology Process of (-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

There total 1 articles about (-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 591-51-5
phenyllithium

: (-)-(2S,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]non-7-ene

: 736180-09-9
(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

Guidance literature:: phenyllithium; With copper(l) iodide; In diethyl ether; cyclohexane; at -78 - -15 ℃; for 0.166667h;

(-)-(2S,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]non-7-ene; In diethyl ether; cyclohexane; at -15 ℃; for 2h; Further stages.;
DOI:10.1039/b404325a

Reference yield: 52.0%

: 736180-09-9
(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

: 736180-10-2
(-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 2h;
DOI:10.1039/b404325a

Reference yield:

: 736180-09-9
(-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane

: 445474-74-8
(-)-(2S,4R)-2-hydroxymethyl-4-phenyl-6-piperidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / TFA / CHCl₃ / 2 h / 20 °C

2: 62 percent / (Bu₃Sn)2O / toluene / 18 h / Heating

With trifluoroacetic acid; bis(tri-n-butyltin)oxide; In chloroform; toluene;
DOI:10.1039/b404325a