(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Base Information

Chemical Name:(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione
CAS No.:637741-50-5
Molecular Formula:C₅₇H₇₈O₁₁
Molecular Weight:939.24
Hs Code.:

(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Synonyms:(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Suppliers and Price of (8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

There total 13 articles about (8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 637741-49-2
(8E,12E,14E)-(3S,4R,5R,10R,11R,16S,17R)-11-Hydroxy-3,4-bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7-dione

: 637741-50-5
(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1039/b305818b

Reference yield:

: 361525-04-4
(2E,4R,5R,6E)-2,4,6-trimethyl-5-(triphenylsiloxy)-7-iodo-2,6-heptadien-1-ol

: 637741-50-5
(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Guidance literature:: Multi-step reaction with 11 steps

1.1: manganese dioxide / CH₂Cl₂ / 12 h / 20 °C

2.1: 1.27 g / sodium chlorite; sodium dihydrogenphosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 20 h / 20 °C

3.1: 79 percent / N,N-dimethylaminopyridine; dicyclohexylcarbodiimide; N,N-dimethylaminopyridine hydrogenchloride / CH₂Cl₂ / 6 h / Heating

4.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C

4.2: K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 0.5 h / 65 °C

5.1: 692 mg / aq. hydrogen fluoride / acetonitrile / 3 h / -10 °C

6.1: Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

7.1: 462 mg / sodium chlorite; sodium dihydrogenphosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 20 h / 20 °C

8.1: 48 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 0.17 h / -78 °C

9.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 2 h / 20 °C

9.2: 40 percent / 4-dimethylaminopyridine / tetrahydrofuran; toluene / 15 h / Heating

10.1: 54 percent / aq. hydrogen fluoride / acetonitrile / 10 h / 0 °C

11.1: 93 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; dmap; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; 9-borabicyclo[3.3.1]nonane dimer; 2-methyl-but-2-ene; N,N-dimethylaminopyridine hydrogenchloride; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol; 3.1: Keck's esterification / 4.1: Suzuki-Miyaura coupling;
DOI:10.1039/b305818b

Reference yield:

: 361525-06-6
1-Methoxy-4-[(1R,2S)-2-methyl-1-((S)-1-methyl-but-2-ynyl)-dodecyloxymethyl]-benzene

: 637741-50-5
(8E,12E,14E)-(3S,4R,5R,10R,16S,17R)-3,4-Bis-(4-methoxy-benzyloxy)-5-(4-methoxy-benzyloxymethyl)-8,10,12,14,16-pentamethyl-17-((S)-1-methyl-undecyl)-1,6-dioxa-cycloheptadeca-8,12,14-triene-2,7,11-trione

Guidance literature:: Multi-step reaction with 10 steps

1.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 °C

2.1: pyridine / CH₂Cl₂ / 3 h / 20 °C

2.2: 938 mg / 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 20 °C

3.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C

3.2: K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 0.5 h / 65 °C

4.1: 692 mg / aq. hydrogen fluoride / acetonitrile / 3 h / -10 °C

5.1: Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

6.1: 462 mg / sodium chlorite; sodium dihydrogenphosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 20 h / 20 °C

7.1: 48 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 0.17 h / -78 °C

8.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 2 h / 20 °C

8.2: 40 percent / 4-dimethylaminopyridine / tetrahydrofuran; toluene / 15 h / Heating

9.1: 54 percent / aq. hydrogen fluoride / acetonitrile / 10 h / 0 °C

10.1: 93 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; sodium chlorite; sodium dihydrogenphosphate; 9-borabicyclo[3.3.1]nonane dimer; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol; 3.1: Suzuki-Miyaura coupling;
DOI:10.1039/b305818b