2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

Base Information

Chemical Name:2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol
CAS No.:321541-10-0
Molecular Formula:C₂₉H₄₅N₃O₅Si₂
Molecular Weight:571.864
Hs Code.:

Synonyms:2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

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Chemical Property of 2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

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Technology Process of 2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

There total 8 articles about 2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 321541-09-7
2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-6,7-O-isopropylidene-D-glycero-D-allo-heptitol

: 321541-10-0
2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

Guidance literature:: With acetic acid; at 20 ℃; for 36h;
DOI:10.1039/b002997l

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 321541-10-0
2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / imidazole / dimethylformamide / 16 h / -25 - 20 °C

2: 92 percent / pyridine / CH₂Cl₂ / 1.5 h / -15 - 0 °C

3: 71 percent / NaN₃ / dimethylformamide / 1 h / 20 °C

4: 64 percent / NaBH₄ / aq. ethanol / 3 h / 20 °C

5: 73 percent / imidazole / dimethylformamide / 16 h / -30 - 20 °C

6: 65 percent / aq. AcOH / 36 h / 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium azide; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b002997l

Reference yield:

: 182195-39-7,502685-24-7
Methyl 2,5-anhydro-D-glycero-D-gulo-heptonate

: 321541-10-0
2,5-Anhydro-4-azido-3-O-(tert-butyldimethylsilyl)-1-O-(tert-butyldiphenylsilyl)-4-deoxy-D-glycero-D-allo-heptitol

Guidance literature:: Multi-step reaction with 7 steps

1: 61 percent / DL-camphor-10-sulfonic acid / acetone / 16 h / 20 °C

2: 72 percent / imidazole / dimethylformamide / 16 h / -25 - 20 °C

3: 92 percent / pyridine / CH₂Cl₂ / 1.5 h / -15 - 0 °C

4: 71 percent / NaN₃ / dimethylformamide / 1 h / 20 °C

5: 64 percent / NaBH₄ / aq. ethanol / 3 h / 20 °C

6: 73 percent / imidazole / dimethylformamide / 16 h / -30 - 20 °C

7: 65 percent / aq. AcOH / 36 h / 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium azide; camphor-10-sulfonic acid; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/b002997l