3,4-dimethoxy,2',4',6'-trihydroxychalcone

Base Information

• Chemical Name: 3,4-dimethoxy,2',4',6'-trihydroxychalcone
• CAS No.: 25515-48-4
• Molecular Formula: C₁₇H₁₆O₆
• Molecular Weight: 316.31
• Mol file: 25515-48-4.mol

Synonyms:3,4-dimethoxy,2',4',6'-trihydroxychalcone

Chemical Property of 3,4-dimethoxy,2',4',6'-trihydroxychalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dimethoxy,2',4',6'-trihydroxychalcone

There total 6 articles about 3,4-dimethoxy,2',4',6'-trihydroxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2'-hydroxy-3,4-dimethoxy-4',6'-bis(methoxymethoxy)chalcone (188842-24-2) → 3,4-dimethoxy,2',4',6'-trihydroxychalcone (25515-48-4)

Guidance literature:

With hydrogenchloride; In methanol; for 0.166667h; Heating;

DOI:10.1016/j.bmc.2007.01.017

Reference yield:

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone (65490-09-7) → 3,4-dimethoxy,2',4',6'-trihydroxychalcone (25515-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / KOH / H₂O; methanol / 75 h / 0 - 20 °C

2: 53 percent / hydrochloric acid / methanol / 0.17 h / Heating

With hydrogenchloride; potassium hydroxide; In methanol; water; 1: Claisen-Schmidt condensation;

DOI:10.1016/j.bmc.2007.01.017

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 3,4-dimethoxy,2',4',6'-trihydroxychalcone (25515-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 2 h / 20 °C

2: KOH / ethanol / 24 h / 20 °C

3: HCl / methanol / 0.5 h / Heating

With hydrogenchloride; potassium hydroxide; potassium carbonate; In methanol; ethanol; acetone; 2: Claisen-Schmidt condensation;

DOI:10.1016/j.bmcl.2005.08.039

upstream raw materials:

(E)-3-(3,4-Dimethoxy-phenyl)-acrylic acid 3,5-dihydroxy-phenyl ester

2'-hydroxy-3,4-dimethoxy-4',6'-bis(methoxymethoxy)chalcone

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

3,4-dimethoxy-benzaldehyde

Refernces

• 1、 Jun, Nishida,Hong, Gao,Jun, Kawabata. "Synthesis and evaluation of 2′,4′,6′-trihydroxychalcones as a new class of tyrosinase inhibitors". . p. 2396 - 2402. Retrieved 2007/10/03.
• 2、 Singh, A.K.,Raghuraman, T.S.. "PHOTOREARRANGEMENT OF PHENYL CINNAMATES UNDER MICELLAR ENVIRONMENT". . p. 4125 - 4128. Retrieved 2007/10/02.