(4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

Base Information

Chemical Name:(4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride
CAS No.:1335283-64-1
Molecular Formula:C₁₈H₁₈N₂O₂*ClH
Molecular Weight:330.814
Hs Code.:

Synonyms:(4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

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Chemical Property of (4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

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Technology Process of (4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

There total 1 articles about (4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 23068-91-9
methyl 5,5-dimethoxyvalerate

: 142-04-1,36663-09-9
aniline hydrochloride

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1335283-64-1
(4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

Guidance literature:: N,N-dimethyl-formamide; With oxalyl dichloride; In dichloromethane; at -78 ℃; for 0.0833333h; Inert atmosphere;

methyl 5,5-dimethoxyvalerate; at 23 - 70 ℃; for 3.42h; Inert atmosphere;

aniline hydrochloride; Further stages;
DOI:10.1021/ja206339s

Reference yield:

: 1335283-64-1
(4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

: C₅₅H₆₇N₂O₁₁⁽¹⁺⁾*Cl^(1-)

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / ethanol / 24 h / 23 - 85 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 30 h / 23 °C / Inert atmosphere

With dmap; sodium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/ja206339s

Reference yield:

: 1335283-64-1
(4E)-5-(phenylamino)-4-((phenylimino)methyl)pent-4-enoic acid hydrochloride

: 1335283-41-4
C₂F₃O₂^(1-)*C₄₇H₅₉N₂O₁₀⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / ethanol / 24 h / 23 - 85 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 30 h / 23 °C / Inert atmosphere

3: methoxybenzene / 0.33 h / 23 °C / Inert atmosphere

With dmap; sodium acetate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/ja206339s