(2R,3S)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

Base Information

Chemical Name:(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide
CAS No.:104946-99-8
Molecular Formula:C₃₂H₅₁NO₂SSi₂
Molecular Weight:569.999
Hs Code.:

Synonyms:(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

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Technology Process of (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

There total 7 articles about (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 104946-98-7
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-pentanethiol

: 107-13-1,25014-41-9
acrylonitrile

: 104946-99-8
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

Guidance literature:: With sodium methylate; In 1,4-dioxane; at 45 ℃; for 1h;
DOI:10.1021/jm00384a026

Reference yield:

: 4390-94-7
1,2-bis(4-methoxyphenyl)butanone

: 104946-99-8
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / NaH, EtSH / dimethylformamide / 19 h / 120 °C

2: 89 percent / imidazole / dimethylformamide / 1 h

3: diethyl ether; hexane / 20 h / Ambient temperature

4: 1.) BH₃*THF, 2.) H₂O, NaOH, H₂O₂ / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h

5: 76 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C

6: 58 percent / LiAlH₄ / diethyl ether / 0.08 h / 0 °C

7: 60 percent / NaOMe / dioxane / 1 h / 45 °C

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; sodium methylate; sodium hydride; triphenylphosphine; ethanethiol; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026

Reference yield:

: 76579-69-6
1,2-bis-(4-hydroxy-phenyl)-butan-1-one

: 104946-99-8
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 2-cyanoethyl sulfide

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / imidazole / dimethylformamide / 1 h

2: diethyl ether; hexane / 20 h / Ambient temperature

3: 1.) BH₃*THF, 2.) H₂O, NaOH, H₂O₂ / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h

4: 76 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C

5: 58 percent / LiAlH₄ / diethyl ether / 0.08 h / 0 °C

6: 60 percent / NaOMe / dioxane / 1 h / 45 °C

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; sodium methylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026