4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

Base Information

Chemical Name:4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole
CAS No.:1198802-79-7
Molecular Formula:C₂₃H₂₅N₃O₅
Molecular Weight:423.469
Hs Code.:

Synonyms:4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

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Chemical Property of 4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

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Technology Process of 4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

There total 4 articles about 4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198409-38-9
6-bromo-4-nitro-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

: 850568-69-3
2-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}tetrahydro-2H-pyran

: 1198802-79-7
4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; isopropyl alcohol; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1198802-79-7
4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1.5 h / Reflux

2: sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol; water / 10 min / 150 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; trifluoroacetic acid; In water; isopropyl alcohol;
DOI:10.1021/acsmedchemlett.7b00296

Reference yield:

: 885518-46-7
6-bromo-4-nitro-1H-indazole

: 1198802-79-7
4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1.5 h / Reflux

2: sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol; water / 10 min / 150 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; trifluoroacetic acid; In water; isopropyl alcohol;
DOI:10.1021/acsmedchemlett.7b00296