(S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

Base Information

Chemical Name:(S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane
CAS No.:173914-63-1
Molecular Formula:C₂₂H₂₉NO₅S
Molecular Weight:419.542
Hs Code.:

Synonyms:(S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

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Chemical Property of (S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

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Technology Process of (S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

There total 5 articles about (S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 124-63-0
methanesulfonyl chloride

: 173914-62-0
(S)-2-tert-butoxycarbonylamino-1,1-diphenylbutan-4-ol

: 173914-63-1
(S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

Guidance literature:: With pyridine; at -10 ℃; for 2.5h;
DOI:10.1016/0957-4166(95)00373-W

Reference yield:

: 158530-68-8
(S)-2-amino-1,1-diphenylbutane-1,4-diol

: 173914-63-1
(S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Li, liq. NH₃, 2.) pyridine, 3.) 2,3-dichloro-5,6-dicyano-1,4-benzoquinone

2: 94 percent / aq. HCl / 6 h / 100 °C

3: 86 percent / tetrahydrofuran / a) 0 deg C, 0.5 h, b) RT, overnight

4: 85 percent / pyridine / 2.5 h / -10 °C

With pyridine; hydrogenchloride; ammonia; lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran;
DOI:10.1016/0957-4166(95)00373-W

Reference yield:

: 173914-59-5
(3S)-3-(acetylamino)-4-hydroxy-4,4-diphenylbutyl acetate

: 173914-63-1
(S)-2-tert-butoxycarbonylamino-4-methanesulphonyloxy-1,1-diphenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / HCOONH₄ / 10percent Pd/C / acetic acid / 8 h / 110 °C

2: 94 percent / aq. HCl / 6 h / 100 °C

3: 86 percent / tetrahydrofuran / a) 0 deg C, 0.5 h, b) RT, overnight

4: 85 percent / pyridine / 2.5 h / -10 °C

With pyridine; hydrogenchloride; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; acetic acid;
DOI:10.1016/0957-4166(95)00373-W