N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

Base Information

Chemical Name:N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide
CAS No.:1468402-79-0
Molecular Formula:C₁₉H₁₁ClF₃NO₂
Molecular Weight:377.75
Hs Code.:

Synonyms:N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

Chemical Property:

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Technology Process of N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

There total 7 articles about N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 57946-56-2
2-fluoro-4-chloroaniline

: 22494-42-4
2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

: 1468402-79-0
N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

Guidance literature:: 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid; With thionyl chloride; In tetrahydrofuran; for 8h; Reflux; Inert atmosphere;

2-fluoro-4-chloroaniline; In tetrahydrofuran; for 14h;

Reference yield:

: 57946-56-2
2-fluoro-4-chloroaniline

: 344348-56-7
C₁₃H₇ClF₂O₂

: 1468402-79-0
N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

Guidance literature:: In tetrahydrofuran; for 14h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2015.05.015

Reference yield:

: 22494-42-4
2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

: 1468402-79-0
N-(4-chloro-2-fluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 8 h / Reflux; Inert atmosphere

2: tetrahydrofuran / 14 h / Inert atmosphere; Reflux

With thionyl chloride; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2015.05.015